inhalation anaesthetic การใช้

• Like all potent inhalation anaesthetic agents it is a known trigger of malignant hyperthermia.
• Amitriptyline increases the CNS depressant action, but not the anticonvulsant action of barbiturates; therefore, an inhalation anaesthetic or diazepam is recommended for control of convulsions . protein binding with amitriptyline.
• Mice in which the TASK-3 gene has been deleted have reduced sensitivity to inhalation anaesthetics, exaggerated nocturnal activity and cognitive deficits as well as significantly increased appetite and weight gain.
• Highlighting the impact of inhalation anaesthetic metabolism and toxicity in the era 1970-1990, his key paper with Richard Mazze on methoxyflurane nephrotoxicity was also in the top 100 most cited papers over the past 60 years.
• Anaesthesia related research themes have encompassed a very broad range of themes : metabolism and renal toxicity of inhalation anaesthetics, antibiotics and NSAIDs  providing the first evidence with Richard Mazze in 1974 of organ toxicity of a drug metabolite ( published in Journal of Pharmacology & Experimental Therapeutics ) as well as multiple related papers; metabolism and hepatoxicity of halothane, utilizing basic and clinical studies to demonstrate both acute metabolite initiated toxicity and delayed metabolite-immune mediated hepatoxicity; toxicity of chronic inhalation of halogenated hydrocarbons; intravenous sedatives and anaesthetics pharmacokinetics, pharmacodynamics and side effects; local anaesthetic pharmacology; epidural and intrathecal neural blockade, pharmacologyy and physiology.